The girl, who was in a safety seat, was pronounced dead at Charles Cole Memorial Hospital in Coudersport.
Police say a car driven by 23-year-old Kelly Bresnahan of Dalton crossed the center line and hit a pickup truck driven by 59-year-old Douglas Merck of Murrysville, and then hit a pickup truck driven by 62-year-old Andrew Chapman Smethport.
Merck and Bresnahan were transported to area hospitals with moderate injuries. A three year-old boy and 27-year-old Tiffany Kowalewski of Mount Cary were flown by helicopter to out of town hospitals for treatment. Chapman wasn't injured.
Police are continuing their investigation.
Route 6 is closed in Roulette Township from Trout Brook Road to Reed Run Road.
Emergency crews are on their way to a three-vehicle crash on Route 6 in Roulette Township.
Emergency radio reports indicate that five people are involved, there is entrapment and at least one person has been ejected.
We'll have more information as it becomes available.