State police say at 6 a.m. a passing motorist saw the fire at 1405 Genesee Mills Road and called 911.
When firefighters arrived the house was engulfed in flames and starting to collapse.
State Police Cpl. Nicholas Loffredo says firefighters found 67-year-old Gary Briggs and 70-year-old Mary Briggs in debris after the fire was out.
Police say no further details are available at this time.